Article
Selection of precore mutants during lamivudine treatment in patients with chronic hepatitis B.
Hepato-gastroenterology - 1 Jan 2000
Cheong Jae Youn, Cho Sung Won, Yoo Jun Hwan, Hong Sun Pyo, Kim Soo-Ok, Yoo Wang Don, Kim Jin Hong
Abstract excerpt
BACKGROUND/AIMS: Evolution of precore genes can occur during lamivudine therapy in HBV infection. This study investigated the changes in precore regions in patients treated with lamivudine and the pattern during relapse. METHODOLOGY: The sequences of codon 28 in precore region in serial samples of 16 patients with HBV (11 HBeAg-positive and 5 HBeAg-negative) treated with lamivudine were analyzed by restriction...
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