Article
Self-peptides from four HLA-DR alleles share hydrophobic anchor residues near the NH2-terminal including proline as a stop signal for trimming.
Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 1993
Kropshofer H, Max H, Halder T, Kalbus M, Muller C A, Kalbacher H
Abstract excerpt
Naturally processed MHC class II-associated peptides proved to be heterogeneous in size, varying from 13 to 25 amino acids. Truncation variants suggested sequence motifs that afford the amino termini to be shifted for obtaining an alignment: a 9- to 11-residue core region that is bordered by primary anchor residues is surrounded by extra sequences of variable lengths and hitherto unknown functions. Herein we...
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