Article
The Peptidome of Behçet's Disease-Associated HLA-B*51:01 Includes Two Subpeptidomes Differentially Shaped by Endoplasmic Reticulum Aminopeptidase 1.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Feb 2016
Guasp Pablo, Alvarez-Navarro Carlos, Gomez-Molina Patricia, Martín-Esteban Adrian, Marcilla Miguel, Barnea Eilon, Admon Arie, López de Castro José A
Abstract excerpt
OBJECTIVE: To characterize the peptidome of the Behçet's disease-associated HLA-B*51:01 allotype as well as the differential features of major peptide subsets and their distinct endoplasmic reticulum aminopeptidase 1 (ERAP-1)-mediated processing. METHODS: The endogenous B*51:01-bound peptidome was characterized from 721.221 transfectant cells, after affinity chromatography and acid extraction, by tandem mass...
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