Article
Pool sequencing of natural HLA-DR, DQ, and DP ligands reveals detailed peptide motifs, constraints of processing, and general rules.
Immunogenetics - 1 Jan 1994
Falk K, Rötzschke O, Stevanović S, Jung G, Rammensee H G
Abstract excerpt
We have approached the problem of MHC class II ligand motifs by pool sequencing natural peptides eluted from HLA-DR, DQ, and DP molecules. The results indicate surprisingly clear patterns, although not quite as clear as with natural class I ligands. The most striking feature is a highly dominant...
Topics
- Alleles
- Amino Acid Sequence
- HLA-DP Antigens
- HLA-DQ Antigens
- HLA-DR Antigens
- Humans
- Ligands
- Molecular Sequence Data
- Peptides
- Protein Conformation
- Protein Processing, Post-Translational