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Article

Mutation of an RSV intronic element abolishes both U11/U12 snRNP binding and negative regulation of splicing.

Genes & development - 1 Oct 1993

Gontarek R R, McNally M T, Beemon K

Abstract excerpt

A cis-acting negative regulator of splicing (NRS) within the gag gene of RSV is involved in control of the relative levels of spliced and unspliced viral mRNAs. Insertion of the NRS into the intron of an adenovirus pre-mRNA resulted in inhibition of splicing in vitro before the first cleavage step. Analyses of spliceosome assembly with this substrate showed that it formed large RNP complexes that did not migrate...

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PMID: 8405999
DOI: 10.1101/gad.7.10.1926

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