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Article

Genetic selection for balanced retroviral splicing: novel regulation involving the second step can be mediated by transitions in the polypyrimidine tract.

Molecular and cellular biology - 1 May 1995

Bouck J, Fu X D, Skalka A M, Katz R A

Abstract excerpt

Incomplete splicing is essential for retroviral replication; and in simple retroviruses, splicing regulation appears to occur entirely in cis. Our previous studies, using avian sarcoma virus, indicated that weak splicing signals allow transcripts to escape the splicing pathway. We also isolated a...

Topics

Animals
Avian Sarcoma Viruses
Base Sequence
Cells, Cultured
Chick Embryo
Gene Expression Regulation, Viral
Genes, Suppressor
Genes, env
Molecular Sequence Data
Mutation
Quail
RNA Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Messenger

RNA, Viral

Selection, Genetic

Transfection

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 7739546
DOI: 10.1128/MCB.15.5.2663
PMCID: PMC230496

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7739546-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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