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Control of human papillomavirus gene expression by alternative splicing

17 Nov 2016

Abstract excerpt

Human papillomaviruses possess circular double stranded DNA genomes of around 8kb in size from which multiple mRNAs are synthesized during an infectious life cycle. Although at least three viral promoters are used to initiate transcription, viral mRNAs are largely the product of processing of pre-mRNAs by alternative splicing and polyadenylation. The HPV life cycle and viral gene expression are tightly linked to...

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PMID: 27867028
DOI: 10.1016/j.virusres.2016.11.016

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