Article
The role of branchpoint and 3'-exon sequences in the control of balanced splicing of avian retrovirus RNA.
Genes & development - 1 Feb 1991
Fu X D, Katz R A, Skalka A M, Maniatis T
Abstract excerpt
We previously described an avian sarcoma-leukosis virus (ASLV) insertion mutation that causes a decrease in the ratio of unspliced to spliced RNA in vivo, resulting in a replication defect. Pseudorevertant viruses containing cis-acting suppressor mutations that restored the normal ratio were isolated. One class of the suppressor mutations consists of single-base changes or small deletions near the 3' splice site,...
Topics
- Avian Sarcoma Viruses
- Base Sequence
- Centrifugation, Density Gradient
- Consensus Sequence
- Exons
- Genes, Suppressor
- Introns
- Molecular Sequence Data
- Mutation
- RNA Precursors
- RNA Splicing