Article
A novel splice donor site in the gag-pol gene is required for HIV-1 RNA stability.
The Journal of biological chemistry - 7 Jul 2006
Lützelberger Martin, Reinert Line S, Das Atze T, Berkhout Ben, Kjems Jørgen
Abstract excerpt
Productive infection and successful replication of human immunodeficiency virus 1 (HIV-1) requires the balanced expression of all viral genes. This is achieved by a combination of alternative splicing events and regulated nuclear export of viral RNA. Because viral splicing is incomplete and intron-containing RNAs must be exported from the nucleus where they are normally retained, it must be ensured that the...
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