Article
Loss of constitutional heterozygosity on chromosome 11p in human ovarian cancer. Positive correlation with grade of differentiation.
Cancer - 15 Oct 1993
Kiechle-Schwarz M, Bauknecht T, Wienker T, Walz L, Pfleiderer A
Abstract excerpt
BACKGROUND: There is increasing evidence suggesting that genes located on the short arm of chromosome 11 play an important role in the development of human ovarian cancer. Recent cytogenetic and molecular studies have demonstrated the loss of genetic material in this region. Loss of normal growth...
Topics
- Adenocarcinoma
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Blotting, Southern
- Cell Differentiation
- Chromosomes, Human, Pair 11
- Female
- Gene Deletion
- Genes, Tumor Suppressor
- Heterozygote