Deletion of chromosome 11p13-11p15.5 sequences in invasive human ovarian cancer is a subclonal progression factor.

Article

Deletion of chromosome 11p13-11p15.5 sequences in invasive human ovarian cancer is a subclonal progression factor.

Cancer research - 1 Dec 1992

Vandamme B, Lissens W, Amfo K, De Sutter P, Bourgain C, Vamos E, De Grève J

Abstract excerpt

In human ovarian cancer, multiple specific chromosomal deletions can be found by cytogenetic analysis or molecular techniques such as restriction fragment length polymorphism probing. This work confirms the loss of HRAS alleles in 1 out of 2 cases of invasive ovarian cancer as determined in 32 sa...

Topics

Adult
Aged
Alleles
Chromosome Deletion
Chromosomes, Human, Pair 11
DNA, Neoplasm
Female
Genes, Suppressor
Genetic Carrier Screening
Humans
Middle Aged
Ovarian Neoplasms

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