Allele loss on chromosome 11p is associated with poor survival in ovarian cancer.

Article

Allele loss on chromosome 11p is associated with poor survival in ovarian cancer.

Disease markers - 1 Jan 2000

Eccles D M, Gruber L, Stewart M, Steel C M, Leonard R C

Abstract excerpt

RFLP (restriction fragment length polymorphism) analysis in 46 ovarian tumour and paired blood samples shows that 33 per cent (5/15) of informative carcinomas had loss of heterozygosity (LOH) at 11p15.4 (Calcitonin locus) and 18% (4/22) had LOH at 11p15.5 (Ha-ras). No LOH was detected in five bor...

Topics

Alleles
Chromosomes, Human, Pair 11
Female
Humans
Ovarian Neoplasms
Polymorphism, Restriction Fragment Length
Prognosis
Survival Analysis

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