Article
Genetic alterations underlying colorectal tumorigenesis.
Cancer surveys - 1 Jan 1992
Fearon E R
Abstract excerpt
Colorectal tumours have proven to be an excellent system in which to identify and study the genetic alterations involved in the development of a common human neoplasm. A prevalent view is that colorectal tumours appear to arise as the result of multiple genetic alterations in the alleles of both oncogenes and tumour suppressor genes. The accumulation of genetic alterations appears to accompany the clinical and...
Topics
- Chromosome Deletion
- Chromosomes, Human, Pair 17
- Chromosomes, Human, Pair 18
- Chromosomes, Human, Pair 5
- Colorectal Neoplasms
- Genes, Tumor Suppressor
- Humans
- Models, Genetic
- Mutation
- Neoplastic Syndromes, Hereditary
- Oncogenes