Genotype-phenotype correlations at the adenomatous polyposis coli (APC) gene.

doi:10.1615/critrevoncog.v6.i3-6.60

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Article

Genotype-phenotype correlations at the adenomatous polyposis coli (APC) gene.

Critical reviews in oncogenesis - 1 Jan 1995

Fodde R, Khan P M

Abstract excerpt

Germline mutations at the adenomatous polyposis (APC) gene are responsible for familial adenomatous polyposis (FAP), an inherited condition that predisposes to the development of hundreds to thousands benign adenomas in the colorectum. If not surgically removed, colorectal adenomas inevitably pro...

Topics

Adenomatous Polyposis Coli
Animals
Disease Models, Animal
Genes, APC
Genotype
Germ-Line Mutation
Humans
Mice
Phenotype

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