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Article

A dominant negative retinoic acid receptor blocks neutrophil differentiation at the promyelocyte stage.

1 Aug 1993

Abstract excerpt

We have investigated the roles of retinoic acid receptors in the development of neutrophils by using an interleukin 3-dependent multipotent hematopoietic cell line (FDCP mix A4) as well as normal mouse bone marrow cells. Treatment of the FDCP mix A4 cells with murine granulocyte/macrophage-colony-stimulating factor (GM-CSF) induced these cells to differentiate into neutrophils and macrophages. When the endogenous...

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PMID: 8394011
DOI: 10.1073/pnas.90.15.7153

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