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Article

Neutrophil elastase is important for PML-retinoic acid receptor alpha activities in early myeloid cells.

Molecular and cellular biology - 1 Jan 2005

Lane Andrew A, Ley Timothy J

Abstract excerpt

Expression of the PML-retinoic acid receptor alpha (PML-RARalpha) fusion protein is the initiating genetic event for acute promyelocytic leukemia (APL), but the molecular mechanisms responsible for disease initiation are not yet clear. Several observations have suggested that early myeloid cells are uniquely susceptible to transformation by PML-RARalpha. Recently, we have shown that the early myeloid-specific...

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Source

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Identifiers

PMID: 15601827
DOI: 10.1128/MCB.25.1.23-33.2005
PMCID: PMC538790

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Neutrophil elastase is important for PML-retinoic acid receptor alpha activities in early myeloid cells.PMID 15601827Read ↗

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Multipotent hematopoietic cell lines derived from C/EBPalpha(-/-) knockout mice display granulocyte macrophage-colony-stimulating factor, granulocyte- colony-stimulating factor, and retinoic acid-induced granulocytic differentiation.Semantic proximity Read ↗

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Role of Promyelocytic Leukemia (Pml) Protein in Tumor SuppressionSemantic proximity Read ↗

Myeloid leukemia with promyelocytic features in transgenic mice expressing hCG-NuMA-RARalpha.Semantic proximity Read ↗

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Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter.Semantic proximity Read ↗

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A dominant negative retinoic acid receptor blocks neutrophil differentiation at the promyelocyte stage.Semantic proximity Read ↗

The Retinoic acid receptor alpha (RARalpha) chimeric proteins PML-, PLZF-, NPM-, and NuMA-RARalpha have distinct intracellular localization patterns.Semantic proximity Read ↗

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