Article
Rosmarinic acid potentiates ATRA-induced macrophage differentiation in acute promyelocytic leukemia NB4 cells.
European journal of pharmacology - 15 Jan 2015
Heo Sook-Kyoung, Noh Eui-Kyu, Yoon Dong-Joon, Jo Jae-Cheol, Koh SuJin, Baek Jin Ho, Park Jae-Hoo, Min Young Joo, Kim Hawk
Abstract excerpt
Rosmarinic acid (RA, an ester of caffeic acid and 3,4-dihydroxyphenyllactic acid) has a number of biological activities, but little is known about anti-leukemic activities of RA combined with all-trans retinoic acid (ATRA) against acute promyelocytic leukemia (APL) cells. We examined the differentiation marker, CD11b, in bone marrow cells (BMC) of an APL patient, in NB4 cells (APL cell line), and in normal BMC...
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