Article
LMP2+ proteasomes are required for the presentation of specific antigens to cytotoxic T lymphocytes.
Current biology : CB - 1 Aug 1995
Sibille C, Gould K G, Willard-Gallo K, Thomson S, Rivett A J, Powis S, Butcher G W, De Baetselier P
Abstract excerpt
BACKGROUND: Major histocompatibility complex (MHC) class I molecules present short peptides generated by intracellular protein degradation to cytotoxic T lymphocytes (CTL). The multisubunit, non-lysosomal proteinases known as proteasomes have been implicated in the generation of these peptides. Two interferon-gamma (IFN-gamma)-inducible proteasome subunits, LMP2 and LMP7, are encoded within the MHC gene cluster...
Topics
- Animals
- Antigen Presentation
- Base Sequence
- Cell Line
- Cysteine Endopeptidases
- Endopeptidases
- Epitopes
- Hemagglutinin Glycoproteins, Influenza Virus
- Hemagglutinins, Viral
- Histocompatibility Antigens Class I