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Article

Stage-specific inhibition of MHC class I presentation by the Epstein-Barr virus BNLF2a protein during virus lytic cycle.

PLoS pathogens - 1 Jun 2009

Croft Nathan P, Shannon-Lowe Claire, Bell Andrew I, Horst Daniëlle, Kremmer Elisabeth, Ressing Maaike E, Wiertz Emmanuel J H J, Middeldorp Jaap M, Rowe Martin, Rickinson Alan B, Hislop Andrew D

Abstract excerpt

The gamma-herpesvirus Epstein-Barr virus (EBV) persists for life in infected individuals despite the presence of a strong immune response. During the lytic cycle of EBV many viral proteins are expressed, potentially allowing virally infected cells to be recognized and eliminated by CD8+ T cells. We have recently identified an immune evasion protein encoded by EBV, BNLF2a, which is expressed in early phase lytic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD8-Positive T-Lymphocytes

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Share to Herpesvirus 4, Human

Share to Histocompatibility Antigens Class I

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Source

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Identifiers

PMID: 19557156
DOI: 10.1371/journal.ppat.1000490
PMCID: PMC2695766

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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