Article
Dmdmdx/Largemyd: a new mouse model of neuromuscular diseases useful for studying physiopathological mechanisms and testing therapies.
Disease models & mechanisms - 1 Sept 2013
Martins Poliana C M, Ayub-Guerrieri Danielle, Martins-Bach Aurea B, Onofre-Oliveira Paula, Malheiros Jackeline M, Tannus Alberto, de Sousa Paulo L, Carlier Pierre G, Vainzof Mariz
Abstract excerpt
Although muscular dystrophies are among the most common human genetic disorders, there are few treatment options available. Animal models have become increasingly important for testing new therapies prior to entering human clinical trials. The Dmd(mdx) mouse is the most widely used animal model for Duchenne muscular dystrophy (DMD), presenting the same molecular and protein defect as seen in humans with the...
Topics
- Adipose Tissue
- Animals
- DNA
- Disease Models, Animal
- Dystrophin
- Female
- Humans
- Imaging, Three-Dimensional
- Male
- Mesenchymal Stem Cell Transplantation
- Mesenchymal Stem Cells
- Mice
- Mice, Inbred mdx