Myogenin gene disruption results in perinatal lethality because of severe muscle defect.

doi:10.1038/364532a0

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Article

Myogenin gene disruption results in perinatal lethality because of severe muscle defect.

Nature - 5 Aug 1993

Nabeshima Y, Hanaoka K, Hayasaka M, Esumi E, Li S, Nonaka I, Nabeshima Y

Abstract excerpt

Myogenin is a member of the basic helix-loop-helix (bHLH) gene family and converts multipotential mesodermal cells to myoblasts. The four members of the myoD family show unique spatio-temporal expression patterns and therefore may have different functions during myogenesis. Here we inactivate the...

Topics

Animals
Animals, Newborn
Base Sequence
Cell Differentiation
Cells, Cultured
Chimera
DNA
Embryo, Mammalian
Female
Genes, Lethal
Genetic Vectors
Heterozygote
Homozygote
Male
Mice
Mice, Inbred Strains
Molecular Sequence Data
Muscle Proteins

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