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Article

Myogenin gene disruption results in perinatal lethality because of severe muscle defect.

Nature - 5 Aug 1993

Nabeshima Y, Hanaoka K, Hayasaka M, Esumi E, Li S, Nonaka I, Nabeshima Y

Abstract excerpt

Myogenin is a member of the basic helix-loop-helix (bHLH) gene family and converts multipotential mesodermal cells to myoblasts. The four members of the myoD family show unique spatio-temporal expression patterns and therefore may have different functions during myogenesis. Here we inactivate the myogenin gene in order to understand its role in myogenesis. Homozygous mutations are lethal perinatally owing to the...

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PMID: 8393146
DOI: 10.1038/364532a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Myogenin gene disruption results in perinatal lethality because of severe muscle defect.PMID 8393146Read ↗

Loss of myogenin in postnatal life leads to normal skeletal muscle but reduced body size.Semantic proximity Read ↗

Myogenin is required for late but not early aspects of myogenesis during mouse development.Semantic proximity Read ↗

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Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene.Semantic proximity Read ↗

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Altered myogenesis in Six1-deficient mice.Semantic proximity Read ↗

Muscular dystrophy candidate gene FRG1 is critical for muscle developmentSemantic proximity Read ↗

Targeted inactivation of myogenic factor genes reveals their role during mouse myogenesis: a review.Semantic proximity Read ↗

Muscular dystrophy begins early in embryonic development deriving from stem cell loss and disrupted skeletal muscle formation.Semantic proximity Read ↗

Thoracic skeletal defects in myogenin- and MRF4-deficient mice correlate with early defects in myotome and intercostal musculature.Semantic proximity Read ↗

Myogenin Regulates Exercise Capacity but Is Dispensable for Skeletal Muscle Regeneration in Adult mdx MiceSemantic proximity Read ↗

Developmental myosins: expression patterns and functional significanceSemantic proximity Read ↗

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