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Article

Dlk1 Is Necessary for Proper Skeletal Muscle Development and Regeneration

29 Nov 2010

Abstract excerpt

Delta-like 1homolog (Dlk1) is an imprinted gene encoding a transmembrane protein whose increased expression has been associated with muscle hypertrophy in animal models. However, the mechanisms by which Dlk1 regulates skeletal muscle plasticity remain unknown. Here we combine conditional gene knockout and over-expression analyses to investigate the role of Dlk1 in mouse muscle development, regeneration and...

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PMID: 21124733
DOI: 10.1371/journal.pone.0015055

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