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Article

K+ channel and alpha 2-adrenergic effects on glucose-induced Ca2+i surges: aberrant behavior in ob/ob mice.

The American journal of physiology - 1 Jun 1993

Fournier L, Whitfield J F, Xiang H, Schwartz J L, Bégin-Heick N

Abstract excerpt

Glucose-induced shifts in intracellular free Ca2+ concentration ([Ca2+]i) were quantitatively and temporally the same in ob/ob and +/+ beta-cells. In both, epinephrine promptly and protractedly inhibited the glucose-induced [Ca2+]i surge via a pertussis toxin-sensitive alpha 2-adrenergic mechanism that was reversible by potassium depolarization. When added before glucose, epinephrine blocked completely in the...

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Source

Identifiers

PMID: 8392795
DOI: 10.1152/ajpcell.1993.264.6.C1458

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