Article
K+ channel and alpha 2-adrenergic effects on glucose-induced Ca2+i surges: aberrant behavior in ob/ob mice.
The American journal of physiology - 1 Jun 1993
Fournier L, Whitfield J F, Xiang H, Schwartz J L, Bégin-Heick N
Abstract excerpt
Glucose-induced shifts in intracellular free Ca2+ concentration ([Ca2+]i) were quantitatively and temporally the same in ob/ob and +/+ beta-cells. In both, epinephrine promptly and protractedly inhibited the glucose-induced [Ca2+]i surge via a pertussis toxin-sensitive alpha 2-adrenergic mechanis...
Topics
- Animals
- Calcium
- Calcium Channel Blockers
- Cyclic AMP
- Epinephrine
- Glucose
- Islets of Langerhans
- Male
- Membrane Potentials
- Mice
- Mice, Inbred C57BL
- Mice, Obese
- Mutation
- Obesity
- Pertussis Toxin
- Potassium Channels
- Sympathomimetics
- Virulence Factors, Bordetella