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Article

Functional roles of the neuropeptide PACAP in brain and pancreas.

Life sciences - 5 Dec 2003

Shintani Norihito, Tomimoto Shuhei, Hashimoto Hitoshi, Kawaguchi Chihiro, Baba Akemichi

Abstract excerpt

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic neuropeptide implicated in a broad variety of physiological processes. To assess PACAP's function in vivo, we recently generated PACAP knockout mice (PACAP(-/-)) and transgenic mice overexpressing PACAP specifically in the pancreas (PACAP-Tg). In PACAP(-/-) mice, we have demonstrated a marked phenotypic changes including a high early...

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Identifiers

PMID: 14607262
DOI: 10.1016/j.lfs.2003.09.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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