Article
Disturbances in glucose-tolerance, insulin-release, and stress-induced hyperglycemia upon disruption of the Ca(v)2.3 (alpha 1E) subunit of voltage-gated Ca(2+) channels.
Molecular endocrinology (Baltimore, Md.) - 1 Apr 2002
Pereverzev Alexey, Mikhna Marina, Vajna Rolf, Gissel Cornelia, Henry Margit, Weiergräber Marco, Hescheler Jürgen, Smyth Neil, Schneider Toni
Abstract excerpt
Multiple types of voltage-activated Ca(2+) channels (T, L, N, P, Q, R type) coordinate Ca(2+)-dependent processes in neurons and neuroendocrine cells. Expressional and functional data have suggested a role for Ca(v)2.3 Ca(2+) channels in endocrine processes. To verify its role in vivo, Ca(v)2.3(-/-) mutant mice were generated, thus deficient in alpha 1E/R-type Ca(2+) channel. Intraperitoneal injection of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.