Article
Separable regulatory elements governing myogenin transcription in mouse embryogenesis.
Science (New York, N.Y.) - 9 Jul 1993
Cheng T C, Wallace M C, Merlie J P, Olson E N
Abstract excerpt
Expression of the myogenic helix-loop-helix (HLH) protein myogenin in muscle cell precursors within somites and limb buds is among the earliest events associated with myogenic lineage determination in vertebrates. Mutations in the myogenin promoter that abolish binding sites for myogenic HLH prot...
Topics
- Animals
- Binding Sites
- DNA-Binding Proteins
- Embryo, Mammalian
- Extremities
- Female
- MEF2 Transcription Factors
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred CBA
- Mice, Transgenic
- Muscle Proteins
- Muscles
- Mutation
- Myogenic Regulatory Factors
- Myogenin
- Promoter Regions, Genetic