Article
MyoD stimulates delta-1 transcription and triggers notch signaling in the Xenopus gastrula.
The EMBO journal - 1 Apr 1999
Wittenberger T, Steinbach O C, Authaler A, Kopan R, Rupp R A
Abstract excerpt
The Notch signaling cascade is involved in many developmental decisions, a paradigm of which has been the selection between epidermal and neural cell fates in both invertebrates and vertebrates. Notch has also been implicated as a regulator of myogenesis, although its precise function there has remained controversial. Here we show that the muscle-determining factor MyoD is a direct, positive regulator of the...
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