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Article

Repression of myogenin function by TGF-beta 1 is targeted at the basic helix-loop-helix motif and is independent of E2A products.

The Journal of biological chemistry - 5 Jun 1992

Martin J F, Li L, Olson E N

Abstract excerpt

The muscle-specific helix-loop-helix (HLH) proteins myogenin, MyoD, myf5, and MRF4 form hetero-oligomers with ubiquitous HLH proteins encoded by the E2A gene and activate muscle transcription by binding to a DNA sequence known as an E-box (CANNTG). Transforming growth factor-beta (TGF-beta) can i...

Topics

Cells, Cultured
Chloramphenicol O-Acetyltransferase
DNA
DNA-Binding Proteins
Muscle Proteins
Mutation
MyoD Protein
Myogenin
Protein Processing, Post-Translational
TCF Transcription Factors
Transcription Factor 7-Like 1 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transcription Factors

Transcription, Genetic

Transfection

Transforming Growth Factor beta

Source

Identifiers

PMID: 1317849

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1317849-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Repression of myogenin function by TGF-beta 1 is targeted at the basic helix-loop-helix motif and is independent of E2A products.PMID 1317849Read ↗

The basic region of myogenin cooperates with two transcription activation domains to induce muscle-specific transcription.Semantic proximity Read ↗

A splice variant of the ITF-2 transcript encodes a transcription factor that inhibits MyoD activity.Semantic proximity Read ↗

HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors.Semantic proximity Read ↗

Negative control of the helix-loop-helix family of myogenic regulators in the NFB mutant.Semantic proximity Read ↗

Separable regulatory elements governing myogenin transcription in mouse embryogenesis.Semantic proximity Read ↗

The TAL1/Scl basic helix-loop-helix protein blocks myogenic differentiation and E-box dependent transactivation.Semantic proximity Read ↗

Sodium butyrate inhibits myogenesis by interfering with the transcriptional activation function of MyoD and myogenin.Semantic proximity Read ↗

Smad7 promotes and enhances skeletal muscle differentiation.Semantic proximity Read ↗

Barx2 is expressed in satellite cells and is required for normal muscle growth and regeneration.Semantic proximity Read ↗

Determinants of myogenic specificity within MyoD are required for noncanonical E box binding.Semantic proximity Read ↗

Characterization of a novel thyroid hormone receptor alpha variant involved in the regulation of myoblast differentiation.Semantic proximity Read ↗

TEAD transcription factors are required for normal primary myoblast differentiation in vitro and muscle regeneration in vivo.Semantic proximity Read ↗

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