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Article

Repression of myogenin function by TGF-beta 1 is targeted at the basic helix-loop-helix motif and is independent of E2A products.

The Journal of biological chemistry - 5 Jun 1992

Martin J F, Li L, Olson E N

Abstract excerpt

The muscle-specific helix-loop-helix (HLH) proteins myogenin, MyoD, myf5, and MRF4 form hetero-oligomers with ubiquitous HLH proteins encoded by the E2A gene and activate muscle transcription by binding to a DNA sequence known as an E-box (CANNTG). Transforming growth factor-beta (TGF-beta) can inhibit muscle differentiation by silencing the transcription-activating potential of myogenic HLH proteins without...

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PMID: 1317849

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Repression of myogenin function by TGF-beta 1 is targeted at the basic helix-loop-helix motif and is independent of E2A products.PMID 1317849Read ↗

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A splice variant of the ITF-2 transcript encodes a transcription factor that inhibits MyoD activity.Semantic proximity Read ↗

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Negative control of the helix-loop-helix family of myogenic regulators in the NFB mutant.Semantic proximity Read ↗

Separable regulatory elements governing myogenin transcription in mouse embryogenesis.Semantic proximity Read ↗

The TAL1/Scl basic helix-loop-helix protein blocks myogenic differentiation and E-box dependent transactivation.Semantic proximity Read ↗

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