Fidelity of DNA replication by extracts of normal and malignantly transformed human cells.

Article

Fidelity of DNA replication by extracts of normal and malignantly transformed human cells.

Cancer research - 15 Jul 1993

Boyer J C, Thomas D C, Maher V M, McCormick J J, Kunkel T A

Abstract excerpt

To test the hypothesis that a mutator phenotype may be associated with carcinogenesis (L. A. Loeb, Cancer Res., 51: 3074-3079, 1991), we have compared the fidelity of double-stranded DNA replication and the efficiency of mismatch repair in extracts from normal diploid and malignantly transformed...

Topics

Cell Line, Transformed
DNA Repair
DNA Replication
DNA, Neoplasm
Escherichia coli
Fibroblasts
HeLa Cells
Humans
Male
Mutation
Neoplasms
Phenotype
Simian virus 40

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