Article
Fidelity of DNA replication by extracts of normal and malignantly transformed human cells.
Cancer research - 15 Jul 1993
Boyer J C, Thomas D C, Maher V M, McCormick J J, Kunkel T A
Abstract excerpt
To test the hypothesis that a mutator phenotype may be associated with carcinogenesis (L. A. Loeb, Cancer Res., 51: 3074-3079, 1991), we have compared the fidelity of double-stranded DNA replication and the efficiency of mismatch repair in extracts from normal diploid and malignantly transformed human cells. Included was a diploid fibroblast strain and its transformed derivative, as well as a second diploid...
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