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Article

Fidelity of animal cell DNA polymerases alpha and delta and of a human DNA replication complex.

Basic life sciences - 1 Jan 1990

Thomas D C, Roberts J D, Fitzgerald M P, Kunkel T A

Abstract excerpt

We are investigating the mechanisms by which mutations are produced or avoided during DNA synthesis. Using in vitro fidelity assays, we have defined the error frequency and mutational specificity of the replicative animal cell DNA polymerases (alpha and delta). With DNA polymerase alpha or the four-subunit DNA polymerase alpha-DNA primase complex, neither of which contains detectable associated exonuclease...

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Identifiers

PMID: 2158293
DOI: 10.1007/978-1-4615-9561-8_24

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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