Fidelity of animal cell DNA polymerases alpha and delta and of a human DNA replication complex.

doi:10.1007/978-1-4615-9561-8_24

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Article

Fidelity of animal cell DNA polymerases alpha and delta and of a human DNA replication complex.

Basic life sciences - 1 Jan 1990

Thomas D C, Roberts J D, Fitzgerald M P, Kunkel T A

Abstract excerpt

We are investigating the mechanisms by which mutations are produced or avoided during DNA synthesis. Using in vitro fidelity assays, we have defined the error frequency and mutational specificity of the replicative animal cell DNA polymerases (alpha and delta). With DNA polymerase alpha or the fo...

Topics

Animals
Cells, Cultured
DNA Polymerase II
DNA Polymerase III
DNA Repair
DNA Replication
DNA, Viral
DNA-Directed DNA Polymerase
Humans
Mutation
Simian virus 40

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