Fidelity of DNA polymerase alpha partially purified from a mutator mutant and wild-type mouse FM3A cells.

Article

Fidelity of DNA polymerase alpha partially purified from a mutator mutant and wild-type mouse FM3A cells.

The Tokai journal of experimental and clinical medicine - 1 Mar 1990

Hyodo M, Suzuki K

Abstract excerpt

Several mutator mutants were isolated from a cultured mouse cell line (FM3A). The mutants exhibited a high rate of spontaneous mutation at three genetic loci of drug resistance. To investigate a possible link between mutator phenotype and fidelity of DNA replication, DNA polymerase alpha was part...

Topics

Animals
Cell Line
DNA Polymerase II
Deoxyribonucleotides
Mice
Mutation
Phenotype

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