Article
Analysis of the multistep process of carcinogenesis using human fibroblasts.
Risk analysis : an official publication of the Society for Risk Analysis - 1 Jun 1994
McCormick J J, Maher V M
Abstract excerpt
Normal human cells in culture have never been neoplastically transformed by carcinogen exposure. One possible explanation is that the life span of such cells is too short for them to acquire the necessary changes. To test this hypothesis, we needed normal human cells with a greatly extended or an infinite life span. We transfected the v-myc gene and a selectable marker into normal human fibroblasts, identified a...
Topics
- Animals
- Carcinogens
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Fibroblasts
- Genes, myc
- Humans
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Neoplasms, Experimental