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Article

Saccharomyces cerevisiae a-factor mutants reveal residues critical for processing, activity, and export.

Eukaryotic cell - 1 Sept 2006

Huyer Gregory, Kistler Amy, Nouvet Franklin J, George Carolyn M, Boyle Meredith L, Michaelis Susan

Abstract excerpt

The Saccharomyces cerevisiae mating pheromone a-factor provides a paradigm for understanding the biogenesis of prenylated fungal pheromones. The biogenesis of a-factor involves multiple steps: (i) C-terminal CAAX modification (where C is cysteine, A is aliphatic, and X is any residue) which includes prenylation, proteolysis, and carboxymethylation (by Ram1p/Ram2p, Ste24p or Rce1p, and Ste14p, respectively); (ii)...

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Identifiers

PMID: 16963638
DOI: 10.1128/EC.00161-06
PMCID: PMC1563590

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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