Article
Relative mitogenic activities of wild-type and retinoblastoma binding-defective SV40 T antigens in serum-deprived and senescent human diploid fibroblasts.
Oncogene - 1 Jul 1993
Sakamoto K, Howard T, Ogryzko V, Xu N Z, Corsico C C, Jones D H, Howard B
Abstract excerpt
A novel gene transfer approach was used to investigate whether the retinoblastoma (Rb)-binding domain of simian virus 40 (SV40) T antigen is required for efficient T antigen-mediated stimulation of DNA synthesis is quiescent or senescent human embryo fibroblasts. In senescent cells, comparison be...
Topics
- Antigens, Polyomavirus Transforming
- Butyrates
- Butyric Acid
- Cell Cycle
- Cell Division
- Cellular Senescence
- DNA
- Fibroblasts
- Humans
- Mitogens
- Mutation
- Receptors, Interleukin-2
- Retinoblastoma Protein
- Simian virus 40