Article
Mutations in the thymidine kinase gene that allow expression of the enzyme in quiescent (G0) cells.
Oncogene - 1 Aug 1991
Kauffman M G, Rose P A, Kelly T J
Abstract excerpt
Thymidine kinase (TK) is a nucleotide salvage pathway enzyme whose activity is highly dependent on the growth state and cell cycle phase of a cell. Cells in the resting or quiescent (G0) phase express very low levels of TK mRNA and protein. When quiescent cells are stimulated to enter the cell cycle by the addition of serum, TK mRNA, activity and polypeptide increase coordinately after about 10-15 h, at the...
Topics
- Animals
- Cells, Cultured
- Fibroblasts
- G1 Phase
- Gene Expression Regulation, Enzymologic
- Mice
- Mutation
- Plasmids
- Protein Biosynthesis
- RNA, Messenger
- Resting Phase, Cell Cycle
- Thymidine Kinase