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Article

The helix-loop-helix protein Id-1 and a retinoblastoma protein binding mutant of SV40 T antigen synergize to reactivate DNA synthesis in senescent human fibroblasts.

Developmental genetics - 1 Jan 1996

Hara E, Uzman J A, Dimri G P, Nehlin J O, Testori A, Campisi J

Abstract excerpt

Normal somatic cells of higher organisms do not divide indefinitely. After a finite number of divisions, normal cells irreversibly cease proliferation by a process termed replicative or cellular senescence. Replicative senescence is controlled by multiple, dominant-acting genes about which very l...

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Identifiers

PMID: 8934878
DOI: 10.1002/(SICI)1520-6408(1996)18:2<161::AID-DVG9>3.0.CO;2-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-8934878-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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The helix-loop-helix protein Id-1 and a retinoblastoma protein binding mutant of SV40 T antigen synergize to reactivate DNA synthesis in senescent human fibroblasts.PMID 8934878Read ↗

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Failure to Phosphorylate the Retinoblastoma Gene Product in Senescent Human FibroblastsSemantic proximity Read ↗

Id1 regulation of cellular senescence through transcriptional repression of p16/Ink4aSemantic proximity Read ↗

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Id-1 Delays Senescence but Does Not Immortalize KeratinocytesSemantic proximity Read ↗

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Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblastsSemantic proximity Read ↗

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