Reduced growth factor requirements and accelerated cell-cycle kinetics in adult human melanocytes transformed with SV40 large T antigen.

doi:10.1111/1523-1747.ep12606981

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Article

Reduced growth factor requirements and accelerated cell-cycle kinetics in adult human melanocytes transformed with SV40 large T antigen.

The Journal of investigative dermatology - 1 May 1995

Zepter K, Häffner A C, Trefzer U, Elmets C A

Abstract excerpt

Melanomas develop with high frequency in transgenic mice in which oncogenic sequences of the SV40 DNA tumor virus have been specifically targeted to melanocytes. To investigate the role of SV40 in melanomagenesis, cultured human melanocytes were transformed with a retroviral shuttle vector encodi...

Topics

Adult
Animals
Antigens, Polyomavirus Transforming
Cell Cycle
Cell Line, Transformed
Fibroblast Growth Factor 2
Humans
Melanocytes
Melanoma
Mice
Mice, Nude
Phenotype
Tumor Cells, Cultured

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