Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Failure to Phosphorylate the Retinoblastoma Gene Product in Senescent Human Fibroblasts

10 Aug 1990

Abstract excerpt

Heterokaryon studies suggest that senescent and quiescent human diploid fibroblasts (HDF) contain a common inhibitor of entry into S phase. DNA synthesis can be induced in senescent and quiescent HDF by fusing them with cells containing DNA viral oncogenes such as SV40 T antigen, adenovirus E1A, or human papillomavirus E7. Both senescent and quiescent HDF contained the unphosphorylated form (p110Rb) of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ocular Oncology and Treatments
Share to Polyomavirus and related diseases
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 2166342
DOI: 10.1126/science.2166342

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Failure to Phosphorylate the Retinoblastoma Gene Product in Senescent Human FibroblastsPMID 2166342Read ↗

Origins of G<sub>1</sub> arrest in senescent human fibroblastsSemantic proximity Read ↗

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblastsSemantic proximity Read ↗

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblastsSemantic proximity Read ↗

Relative mitogenic activities of wild-type and retinoblastoma binding-defective SV40 T antigens in serum-deprived and senescent human diploid fibroblasts.Semantic proximity Read ↗

The helix-loop-helix protein Id-1 and a retinoblastoma protein binding mutant of SV40 T antigen synergize to reactivate DNA synthesis in senescent human fibroblasts.Semantic proximity Read ↗

Loss of retinoblastoma but not p16 function allows bypass of replicative senescence in human fibroblastsSemantic proximity Read ↗

Differential Roles for Cyclin-Dependent Kinase Inhibitors p21 and p16 in the Mechanisms of Senescence and Differentiation in Human FibroblastsSemantic proximity Read ↗

Replicatively senescent cells are arrested in G1 and G2 phasesSemantic proximity Read ↗

Lack of Elk-1 phosphorylation and dysregulation of the extracellular regulated kinase signaling pathway in senescent human fibroblast.Semantic proximity Read ↗

p35 Is Required for CDK5 Activation in Cellular SenescenceSemantic proximity Read ↗

A G1 checkpoint mediated by the retinoblastoma protein that is dispensable in terminal differentiation but essential for senescence.Semantic proximity Read ↗

Deregulation of cyclins D1 and E and suppression of cdk2 and cdk4 in senescent human fibroblastsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.