Article
Association between wild type and mutant APC gene products.
Cancer research - 15 Jun 1993
Su L K, Johnson K A, Smith K J, Hill D E, Vogelstein B, Kinzler K W
Abstract excerpt
Germline mutations of the APC gene are responsible for familial adenomatous polyposis, an autosomal dominant inherited predisposition to colorectal tumors. Mutation of the APC gene is also an early, if not initiating, event for sporadic colorectal tumorigenesis. In both cases, almost all of the currently identified mutations of APC result in the truncation of the protein. In this study, we demonstrate that...
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