Mutations in the APC gene and their implications for protein structure and function.

doi:10.1016/s0959-437x(95)90055-1

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Article

Mutations in the APC gene and their implications for protein structure and function.

Current opinion in genetics & development - 1 Feb 1995

Polakis P

Abstract excerpt

An enormous number of germline and somatic mutations have been identified in the APC tumor suppressor gene. Nearly all of these mutations result in premature polypeptide chain termination, but the consequences to APC protein function are unknown. Recent advances, including the identification of a...

Topics

Adenomatous Polyposis Coli Protein
Animals
Cytoskeletal Proteins
Genes, APC
Humans
Mutation
Protein Conformation
Structure-Activity Relationship

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