Article
Evidence against dominant negative mechanisms of intestinal polyp formation by Apc gene mutations.
Cancer research - 1 Jul 1995
Oshima M, Oshima H, Kobayashi M, Tsutsumi M, Taketo M M
Abstract excerpt
Mutations in the adenomatous polyposis coli (APC) gene are responsible for not only familial adenomatous polyposis but also many sporadic cancers of the digestive tract. Most mutations found in familial adenomatous polyposis patients are of the truncation type, and the phenotype is affected by the mutation sites in the gene. Truncated APC proteins can associate with the wild-type protein. Accordingly, it has been...
Topics
- Adenomatous Polyposis Coli Protein
- Amino Acid Sequence
- Animals
- Cytoskeletal Proteins
- Genes, Dominant
- Genes, Tumor Suppressor
- Humans
- Intestinal Polyps
- Intestine, Small
- Mice
- Mice, Transgenic