Article
The APC gene product in normal and tumor cells.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1993
Smith K J, Johnson K A, Bryan T M, Hill D E, Markowitz S, Willson J K, Paraskeva C, Petersen G M, Hamilton S R, Vogelstein B
Abstract excerpt
The APC gene has been found to be mutated during the development of sporadic colorectal tumors as well as in the germ line of familial adenomatous polyposis patients. To facilitate the characterization of both normal and mutant APC protein, a series of monoclonal and polyclonal antibodies specific for the APC protein was produced. When lymphoblastoid cell lines derived from seven familial adenomatous polyposis...
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