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Article

Development of candidates for new type 2 and type 3 oral poliovirus vaccines.

Developments in biological standardization - 1 Jan 1993

Kohara M, Abe S, Yoshioka I, Nomoto A

Abstract excerpt

Monkey neurovirulence tests on in vitro recombinant viruses between the virulent Mahoney and the attenuated Sabin 1 strains of type 1 poliovirus revealed that a strong neurovirulence determinant(s) resided in the 5' non-coding sequence of the genome and that the surface structure of the virion particle had a little correlation with the neurovirulence or attenuation phenotype. The results suggested that new and...

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PMID: 8388824

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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