Development of candidates for new type 2 and type 3 oral poliovirus vaccines.

Article

Development of candidates for new type 2 and type 3 oral poliovirus vaccines.

Developments in biological standardization - 1 Jan 1993

Kohara M, Abe S, Yoshioka I, Nomoto A

Abstract excerpt

Monkey neurovirulence tests on in vitro recombinant viruses between the virulent Mahoney and the attenuated Sabin 1 strains of type 1 poliovirus revealed that a strong neurovirulence determinant(s) resided in the 5' non-coding sequence of the genome and that the surface structure of the virion pa...

Topics

Animals
Biological Assay
Capsid
Macaca fascicularis
Phenotype
Poliomyelitis
Poliovirus
Poliovirus Vaccine, Oral
Recombination, Genetic
Safety
Serotyping
Virulence

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