Article
Nonrandom cytogenetic changes accompany malignant progression in clonal lines abelson virus-infected lymphocytes.
Blood - 15 Dec 1994
Clark S S, Liang Y, Reedstrom C K, Wu S Q
Abstract excerpt
Initially, lymphoid cells transformed by v-abl or BCR/ABL oncogenes are poorly oncogenic but progress to full transformation over time. Although expression of the oncogene is necessary to initiate and maintain transformation, other molecular mechanisms are thought to be required for full transfor...
Topics
- Abelson murine leukemia virus
- Animals
- Bone Marrow Cells
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Cell Transformation, Viral
- Chromosome Aberrations
- Clone Cells
- DNA, Viral
- Female
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Genes, abl
- Lymphocytes
- Lymphoma
- Mice
- Mice, Inbred BALB C
- Neoplasm Transplantation
- Phenotype