Article
The use of the tyrosine phosphatase antagonist orthovanadate in the study of a cell proliferation inhibitor.
Transactions of the Kansas Academy of Science. Kansas Academy of Science - 1 Apr 1993
Enebo D J, Hanek G, Fattaey H K, Johnson T C
Abstract excerpt
Incubation of murine fibroblasts with orthovanadate, a global tyrosine phosphatase inhibitor, was shown to confer a "pseudo-transformed" phenotype with regard to cell morphology and growth characteristics. This alteration was manifested by both an increasing refractile appearance of the cells, consistent with many transformed cell lines, as well as an increase in maximum cell density was attained. Despite the...
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