Article
Disruption of the transthyretin gene results in mice with depressed levels of plasma retinol and thyroid hormone.
Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 1993
Episkopou V, Maeda S, Nishiguchi S, Shimada K, Gaitanaris G A, Gottesman M E, Robertson E J
Abstract excerpt
Transthyretin (TTR) is thought to play a major role in vitamin A metabolism and thyroid hormone transport in mammals. To investigate the physiological role of the TTR protein in development of the embryo and in the adult, we used gene targeting techniques to generate a null mutation at the mouse...
Topics
- Animals
- Base Sequence
- Blotting, Southern
- Clone Cells
- Crosses, Genetic
- DNA
- Female
- Genetic Vectors
- Genotype
- Heterozygote
- Homozygote
- Male
- Mice
- Mice, Inbred Strains
- Molecular Sequence Data