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Article

Thyroid hormone resistance and increased metabolic rate in the RXR-gamma-deficient mouse.

The Journal of clinical investigation - 1 Jul 2000

Brown N S, Smart A, Sharma V, Brinkmeier M L, Greenlee L, Camper S A, Jensen D R, Eckel R H, Krezel W, Chambon P, Haugen B R

Abstract excerpt

Vitamin A and retinoids affect pituitary-thyroid function through suppression of serum thyroid-stimulating hormone (TSH) levels and TSH-beta subunit gene expression. We have previously shown that retinoid X receptor-selective (RXR-selective) ligands can suppress serum TSH levels in vivo and TSH-beta promoter activity in vitro. The RXR-gamma isotype has limited tissue distribution that includes the thyrotrope...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10880050
DOI: 10.1172/JCI9422
PMCID: PMC314362

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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