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Article

Marked resistance of RAR gamma-deficient mice to the toxic effects of retinoic acid.

The American journal of physiology - 1 Jul 1995

Look J, Landwehr J, Bauer F, Hoffmann A S, Bluethmann H, LeMotte P

Abstract excerpt

Excessive intake of retinol or of retinoic acid causes a syndrome of characteristic toxic effects known as hypervitaminosis A. To test the role of the nuclear retinoic acid receptor (RAR gamma) in this process we produced mice with a targeted disruption of the RAR gamma gene and examined toxic ef...

Topics

Animals
Base Sequence
Benzoates
Drug Resistance
Mice
Mice, Mutant Strains
Molecular Probes
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutation
Receptors, Retinoic Acid
Retinoids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Skin

Tetrahydronaphthalenes

Tretinoin

Retinoic Acid Receptor gamma

Source

Identifiers

PMID: 7631783
DOI: 10.1152/ajpendo.1995.269.1.E91

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7631783-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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