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Article

Marked resistance of RAR gamma-deficient mice to the toxic effects of retinoic acid.

The American journal of physiology - 1 Jul 1995

Look J, Landwehr J, Bauer F, Hoffmann A S, Bluethmann H, LeMotte P

Abstract excerpt

Excessive intake of retinol or of retinoic acid causes a syndrome of characteristic toxic effects known as hypervitaminosis A. To test the role of the nuclear retinoic acid receptor (RAR gamma) in this process we produced mice with a targeted disruption of the RAR gamma gene and examined toxic effects of repeated doses of retinoic acid and two other synthetic retinoids, Ro 15-1570 and Ro 40-6055. Surprisingly,...

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Identifiers

PMID: 7631783
DOI: 10.1152/ajpendo.1995.269.1.E91

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