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Article

Inconsistency between hepatic expression and serum concentration of transthyretin in mice humanized at the transthyretin locus.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Dec 2008

Zhao Gang, Li Zhenghua, Araki Kimi, Haruna Kyoko, Yamaguchi Kazuhito, Araki Masatake, Takeya Motohiro, Ando Yukio, Yamamura Ken-ichi

Abstract excerpt

Human transthyretin (TTR) has about 110 variants, more than 90 of which are associated with human amyloidosis. Several groups have generated transgenic mice that carry various mutant TTR genes. However, formation of mouse/human TTR heterotetramers has been shown to be inhibitory to dissociation and subsequent amyloid formation. To avoid the effect of mouse Ttr and produce humanized mice carrying different TTR...

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Source

Identifiers

PMID: 19032346
DOI: 10.1111/j.1365-2443.2008.01242.x

Genes

TTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inconsistency between hepatic expression and serum concentration of transthyretin in mice humanized at the transthyretin locus.PMID 19032346Read ↗

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