Article
Vitamin A-sensitive tissues in transgenic mice expressing high levels of human cellular retinol-binding protein type I are not altered phenotypically.
The Journal of nutrition - 1 Sept 1999
Trøen G, Eskild W, Fromm S H, De Luca L M, Ong D E, Wardlaw S A, Reppe S, Blomhoff R
Abstract excerpt
The suggested function of cellular retinol-binding protein type I [CRBP(I)] is to carry retinol to esterifying or oxidizing enzymes. The retinyl esters are used in storage or transport, whereas oxidized forms such as all-trans or 9-cis retinoic acid are metabolites used in the mechanism of action of vitamin A. Thus, high expression of human CRBP(I) [hCRBP(I)] in transgenic mice might be expected to increase the...
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